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Cosmo Bio USA/Anti CD44 Antigen v9 mAb (Clone RV3)/CAC-LKG-M003/CAC-LKG-M003-50 µg
Cosmo Bio USA/Anti CD44 Antigen v9 mAb (Clone RV3)/CAC-LKG-M003/CAC-LKG-M003-50 µg
商品编号：
CAC-LKG-M003-50µg
市场价：
¥13240.00
美元价：
7944.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Application:FC,IP,ELISA,IF,IHC(p),WB,ICCClonality:MonoclonalHost:RatPurification:Ig-PGReactivity:HumanCD44isasingle-passtypeItransmembraneproteinandfunctionsasacellularadhesionmoleculeforhyaluronicacid,amajorcomponentoftheextracellularmatrix.ItexistsinnumerousisoformsthataregeneratedthroughalternativesplicingofCD44precursormRNA.WhereasthestandardisoformofCD44(CD44s)isexpressedpredominantlyinhematopoieticcellsandnormalepithelialcellsubsets,CD44v(variant)isoforms,whichcontainadditionalinsertionsinthemembrane-proximalextracellularregion,arehighlyexpressedinepithelial-typecarcinomas.Moreover,CD44isreportedtobeacellsurfaceMarkerforcancerstemcells(CSCs)derivedfromsolidtumorsincludingbreast,prostate,colon,headandneckandpancreaticcancer.ExpressionofCD44,especiallyvariantisoforms(CD44v8-10),contributestoreactiveoxygenspecies(ROS)defensethroughupregulationofthesynthesisofreducedglutathione(GSH),theprimaryintracellularantioxidant.CD44v8-10interactswithandstABIlizesxCT,asubunitofthecystine-glutamatetransporterxc(-),andtherebypromotescystineuptakeforGSHsynthesis.TheabilitytoavoidtheconsequencesofexposuretohighlevelsofROSisrequiredforcancercellsurvivalandpropagationinvivo.CSCs(whosedefenseagainstROSisenhancedbyCD44v8-10)arethusthoughttodrivetumorgrowth,chemoresistanceandmetastasis.CloneRV3(amonoclonalantibodyspecificforhumanCD44v9)canbeusedinflowcytometry,andimportantly,fortheenrichmentofCSCsusingFACS.RV3canbeappliedtowardsunderstandingavarietyofmolecularmechanismsandtowardsthedevelopmentofnewmedicinesagainstcancerstemcellsusinginvitrocell-basedassayssuchasthe"invitrosphereformation"and"invivolungmetastasis"assays.References:1)NaganoO.,etal.,Oncogene.2013Jan21.,1-8.PMID:233343332)IshimotoT.,etal.,CancerCell.2011Mar8;19(3):387-400.PMID:213978613)YaeT.,etal.,NatCommun.2012Jun6;3:883.PMID:226739104)TsugawaH.,etal.,CellHostMicrobe.2012Dec13;12(6):764-77.PMID:232453215)TanabeKK.,etal.,Lancet.1993Mar20;341(8847):725-6.PMID:8095628
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